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Protein Labeling and Crosslinking by Covalent Aptamers
We developed a new approach to selectively modify native proteins in their biological environment using electrophilic covalent aptamers. These aptamers are generated through introduction of a proximity-driven electrophile at specific nucleotide sites. Using thrombin as a proof-of-concept, we demonst...
Sparad:
| I publikationen: | Angew Chem Int Ed Engl |
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| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2021
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8260448/ https://ncbi.nlm.nih.gov/pubmed/33928724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202101174 |
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