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Safety and Efficacy of Daratumumab in Patients with Proliferative GN with Monoclonal Immunoglobulin Deposits

BACKGROUND: Treatment of proliferative GN with monoclonal Ig deposits (PGNMID) is not established. A monoclonal anti-CD38 antibody (daratumumab) is effective in treating multiple myeloma. Abnormal plasma cell clones may play a role in the pathogenesis of PGNMID. METHODS: We evaluated daratumumab’s s...

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Pubblicato in:J Am Soc Nephrol
Autori principali: Zand, Ladan, Rajkumar, S. Vincent, Leung, Nelson, Sethi, Sanjeev, El Ters, Mireille, Fervenza, Fernando C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259683/
https://ncbi.nlm.nih.gov/pubmed/33685975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020101541
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