Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier

BACKGROUND: Crumbs2 is expressed at embryonic stages as well as in the retina, brain, and glomerular podocytes. Recent studies identified CRB2 mutations as a novel cause of steroid-resistant nephrotic syndrome (SRNS). METHODS: To study the function of Crb2 at the renal filtration barrier, mice lacki...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Möller-Kerutt, Annika, Rodriguez-Gatica, Juan E., Wacker, Karin, Bhatia, Rohan, Siebrasse, Jan-Peter, Boon, Nanda, Van Marck, Veerle, Boor, Peter, Kubitscheck, Ulrich, Wijnholds, Jan, Pavenstädt, Hermann, Weide, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2021
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259666/
https://ncbi.nlm.nih.gov/pubmed/33687977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020040501
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