Bosutinib reduces endothelial permeability and organ failure in a rat polytrauma transfusion model()

BACKGROUND: Trauma-induced shock is associated with endothelial dysfunction. We examined whether the tyrosine kinase inhibitor bosutinib as an adjunct therapy to a balanced blood component resuscitation strategy reduces trauma-induced endothelial permeability, thereby improving shock reversal and li...

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Publicat a:Br J Anaesth
Autors principals: Kleinveld, Derek J.B., Botros, Liza, Maas, M. Adrie W., Kers, Jesper, Aman, Jurjan, Hollmann, Markus W., Juffermans, Nicole P.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Critical Care
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258973/
https://ncbi.nlm.nih.gov/pubmed/33685634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2021.01.032
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