Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ

Nuclear receptors (NRs) activate transcription of target genes in response to binding of ligands to their ligand-binding domains (LBDs). Typically, in vitro assays use either gene expression or the recruitment of coactivators to the isolated LBD of the NR of interest to measure NR activation. Howeve...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Kilu, Whitney, Merk, Daniel, Steinhilber, Dieter, Proschak, Ewgenij, Heering, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258697/
https://ncbi.nlm.nih.gov/pubmed/34081964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100814
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