Morphine and fentanyl exposure during therapeutic hypothermia does not impair neurodevelopment

BACKGROUND: Hypothermia-treated and intubated infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) usually receive morphine for sedation and analgesia (SA) during therapeutic hypothermia (TH) and endotracheal ventilation. Altered drug pharmacokinetics in this population increases th...

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Publicat a:EClinicalMedicine
Autors principals: Gundersen, Julia K, Chakkarapani, Ela, Jary, Sally, Menassa, David A, Scull-Brown, Emma, Frymoyer, Adam, Walløe, Lars, Thoresen, Marianne
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257990/
https://ncbi.nlm.nih.gov/pubmed/34308308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eclinm.2021.100892
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