DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis

Alternative promoter usage generates long and short isoforms (DCLK1-L and DCLK1-S) of doublecortin-like kinase-1 (DCLK1). Tight control of Notch signaling is important to prevent and restitute inflammation in the intestine. Our aim was to investigate whether Notch1–DCLK1 axis regulates the mucosal i...

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Publicado en:Cell Death Discov
Main Authors: Roy, Badal C., Ahmed, Ishfaq, Stubbs, Jason, Zhang, Jun, Attard, Thomas, Septer, Seth, Welch, Danny, Anant, Shrikant, Sampath, Venkatesh, Umar, Shahid
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257684/
https://ncbi.nlm.nih.gov/pubmed/34226497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00526-9
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