DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis

Alternative promoter usage generates long and short isoforms (DCLK1-L and DCLK1-S) of doublecortin-like kinase-1 (DCLK1). Tight control of Notch signaling is important to prevent and restitute inflammation in the intestine. Our aim was to investigate whether Notch1–DCLK1 axis regulates the mucosal i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Discov
Prif Awduron: Roy, Badal C., Ahmed, Ishfaq, Stubbs, Jason, Zhang, Jun, Attard, Thomas, Septer, Seth, Welch, Danny, Anant, Shrikant, Sampath, Venkatesh, Umar, Shahid
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257684/
https://ncbi.nlm.nih.gov/pubmed/34226497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00526-9
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