TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes

The Hippo signaling effector, TEAD1 plays an essential role in cardiovascular development. However, a role for TEAD1 in postmitotic cardiomyocytes (CMs) remains incompletely understood. Herein we reported that TEAD1 is required for postmitotic CM survival. We found that adult mice with ubiquitous or...

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Publié dans:Cell Death Differ
Auteurs principaux: Liu, Jinhua, Wen, Tong, Dong, Kunzhe, He, Xiangqin, Zhou, Hongyi, Shen, Jian, Fu, Zurong, Hu, Guoqing, Ma, Wenxia, Li, Jie, Wang, Wenjuan, Wang, Liang, Akerberg, Brynn N., Xu, Jiqian, Osman, Islam, Zheng, Zeqi, Wang, Wang, Du, Quansheng, Pu, William T., Xiang, Meixiang, Chen, Weiqin, Su, Huabo, Zhang, Wei, Zhou, Jiliang
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257617/
https://ncbi.nlm.nih.gov/pubmed/33469230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00732-5
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