Deep sequencing of 1320 genes reveals the landscape of protein-truncating variants and their contribution to psoriasis in 19,973 Chinese individuals

Protein-truncating variants (PTVs) have important impacts on phenotype diversity and disease. However, their population genetics characteristics in more globally diverse populations are not well defined. Here, we describe patterns of PTVs in 1320 genes sequenced in 10,539 healthy controls and 9434 p...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Xu, Huixin, Zhen, Qi, Bai, Mingzhou, Fang, Lin, Zhang, Yong, Li, Bao, Ge, Huiyao, Moon, Sunjin, Chen, Weiwei, Fu, Wenqing, Xu, Qiongqiong, Zhou, Yuwen, Yu, Yafeng, Lin, Long, Yong, Liang, Zhang, Tao, Chen, Shirui, Liu, Siyang, Zhang, Hui, Chen, Ruoyan, Cao, Lu, Zhang, Yuanwei, Zhang, Ruixue, Yang, Huanjie, Hu, Xia, Akey, Joshua M., Jin, Xin, Sun, Liangdan
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256863/
https://ncbi.nlm.nih.gov/pubmed/34155038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.267963.120
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