Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting

Translation of open reading frame 1b (ORF1b) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires a programmed −1 ribosomal frameshift (−1 PRF) promoted by an RNA pseudoknot. The extent to which SARS-CoV-2 replication may be sensitive to changes in −1 PRF efficiency is currently...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Sun, Yu, Abriola, Laura, Niederer, Rachel O., Pedersen, Savannah F., Alfajaro, Mia M., Silva Monteiro, Valter, Wilen, Craig B., Ho, Ya-Chi, Gilbert, Wendy V., Surovtseva, Yulia V., Lindenbach, Brett D., Guo, Junjie U.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2021
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256030/
https://ncbi.nlm.nih.gov/pubmed/34185680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023051118
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