Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures

Background: Baicalin (BCL), a candidate drug for ischemic stroke, has been indicated to protect neurons by promoting brain-derived neurotrophic factor (BDNF). However, the cellular source of BDNF release promoted by baicalin and its detailed protective mechanism after ischemia/reperfusion remains to...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Li, Changxiang, Sui, Conglu, Wang, Wei, Yan, Juntang, Deng, Nan, Du, Xin, Cheng, Fafeng, Ma, Xiaona, Wang, Xueqian, Wang, Qingguo
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255628/
https://ncbi.nlm.nih.gov/pubmed/34234667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.599543
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