GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis

Idiopathic pulmonary fibrosis (IPF) is mainly characterized by aberrant extracellular matrix deposition, consequent to epithelial lung injury and myofibroblast activation, and inflammatory response. Glycogen synthase kinase 3 (GSK-3) is a serine–threonine kinase involved in several pathways, and its...

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Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Cinetto, Francesco, Ceccato, Jessica, Caputo, Ilaria, Cangiano, Daniela, Montini, Barbara, Lunardi, Francesca, Piazza, Maria, Agostini, Carlo, Calabrese, Fiorella, Semenzato, Gianpietro, Rattazzi, Marcello, Gurrieri, Carmela, Scarpa, Riccardo, Felice, Carla, Vianello, Fabrizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255387/
https://ncbi.nlm.nih.gov/pubmed/34235177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.633054
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