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Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids
BACKGROUND: Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting fibroid growth, but no prior studies have tested e...
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| Publicado no: | Clin Transl Med |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8255059/ https://ncbi.nlm.nih.gov/pubmed/34323413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.475 |
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