The N2N3 domains of ClfA, FnbpA and FnbpB in Staphylococcus aureus bind to human complement factor H, and their antibodies enhance the bactericidal capability of human blood

In the complement system, the opsonin C3b binds to the bacterial cell surface and mediates the opsonophagocytosis. However, the cell-wall protein SdrE of Staphylococcus aureus inhibits the C3b activity by recruiting the complement regulatory protein factor H (fH). SdrE binds to fH via its N-terminal...

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Библиографические подробности
Опубликовано в: :J Biochem
Главные авторы: Mao, Xinrui, Kim, Junghyun, Zhang, QingFeng, Jiang, TingTing, Ahn, Dong Ho, Jung, Yunjin, Matsushita, Misao, Bae, Taeok, Lee, Bok Luel
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Regular Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254515/
https://ncbi.nlm.nih.gov/pubmed/33326036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jb/mvaa142
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