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Exploring the sequence features determining amyloidosis in human antibody light chains

The light chain (AL) amyloidosis is caused by the aggregation of light chain of antibodies into amyloid fibrils. There are plenty of computational resources available for the prediction of short aggregation-prone regions within proteins. However, it is still a challenging task to predict the amyloid...

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Udgivet i:Sci Rep
Main Authors: Rawat, Puneet, Prabakaran, R., Kumar, Sandeep, Gromiha, M. Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253744/
https://ncbi.nlm.nih.gov/pubmed/34215782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93019-9
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