Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes

Ovarian carcinomas (OCs) are poorly immunogenic and immune checkpoint inhibitors (ICIs) have offered a modest benefit. In this study, high CD3(+) T-cells and CD163(+) tumor-associated macrophages (TAMs) densities identify a subgroup of immune infiltrated high-grade serous carcinomas (HGSCs) with bet...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Ardighieri, Laura, Missale, Francesco, Bugatti, Mattia, Gatta, Luisa Benerini, Pezzali, Irene, Monti, Matilde, Gottardi, Stefano, Zanotti, Laura, Bignotti, Eliana, Ravaggi, Antonella, Tognon, Germana, Odicino, Franco, Calza, Stefano, Missolo-Koussou, Yoann, Ries, Carola Hermine, Helft, Julie, Vermi, William
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253056/
https://ncbi.nlm.nih.gov/pubmed/34220848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.690201
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