Less is More: We are Administering Too Much Protamine in Cardiac Surgery

CONTEXT: Protamine is routinely administered to neutralize the anticlotting effects of heparin, traditionally at a dose of 1 mg for every 100 IU of heparin—a 1:1 ratio protamine sparing effects—but this is based more on experience and practice than literature evidence. The use of Hemostasis Manageme...

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Vydáno v:Ann Card Anaesth
Hlavní autoři: De Simone, Francesco, Nardelli, Pasquale, Licheri, Margherita, Frau, Giovanna, Redaelli, Martina Baiardo, Monaco, Fabrizio, Zangrillo, Alberto, Landoni, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer - Medknow 2021
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253032/
https://ncbi.nlm.nih.gov/pubmed/33884973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/aca.ACA_26_19
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