Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity

Subtype selectivity represents a challenge in many drug discovery campaigns. A typical example is the FK506 binding protein 51 (FKBP51), which has emerged as an attractive drug target. The most advanced FKBP51 ligands of the SAFit class are highly selective vs. FKBP52 but poorly discriminate against...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Angew Chem Int Ed Engl
Egile Nagusiak: Voll, Andreas M., Meyners, Christian, Taubert, Martha C., Bajaj, Thomas, Heymann, Tim, Merz, Stephanie, Charalampidou, Anna, Kolos, Jürgen, Purder, Patrick L., Geiger, Thomas M., Wessig, Pablo, Gassen, Nils C., Bracher, Andreas, Hausch, Felix
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2021
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252719/
https://ncbi.nlm.nih.gov/pubmed/33843131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202017352
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