carba Nicotinamide Adenine Dinucleotide Phosphate: Robust Cofactor for Redox Biocatalysis

Here we report a new robust nicotinamide dinucleotide phosphate cofactor analog (carba‐NADP(+)) and its acceptance by many enzymes in the class of oxidoreductases. Replacing one ribose oxygen with a methylene group of the natural NADP(+) was found to enhance stability dramatically. Decomposition exp...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Zachos, Ioannis, Döring, Manuel, Tafertshofer, Georg, Simon, Robert C., Sieber, Volker
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252718/
https://ncbi.nlm.nih.gov/pubmed/33719153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202017027
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