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Constant regulation for stable CD8 T‐cell functional avidity and its possible implications for cancer immunotherapy
The functional avidity (FA) of cytotoxic CD8 T cells impacts strongly on their functional capabilities and correlates with protection from infection and cancer. FA depends on TCR affinity, downstream signaling strength, and TCR affinity‐independent parameters of the immune synapse, such as costimula...
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| Veröffentlicht in: | Eur J Immunol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8252569/ https://ncbi.nlm.nih.gov/pubmed/33704770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.202049016 |
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