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Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound

The regulation of enzyme activity is a method to control biological function. We report two systems enabling the ultrasound‐induced activation of thrombin, which is vital for secondary hemostasis. First, we designed polyaptamers, which can specifically bind to thrombin, inhibiting its catalytic acti...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Zhao, Pengkun, Huo, Shuaidong, Fan, Jilin, Chen, Junlin, Kiessling, Fabian, Boersma, Arnold J., Göstl, Robert, Herrmann, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252103/
https://ncbi.nlm.nih.gov/pubmed/33939872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202105404
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