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Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound

The regulation of enzyme activity is a method to control biological function. We report two systems enabling the ultrasound‐induced activation of thrombin, which is vital for secondary hemostasis. First, we designed polyaptamers, which can specifically bind to thrombin, inhibiting its catalytic acti...

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Библиографические подробности
Опубликовано в: :Angew Chem Int Ed Engl
Главные авторы: Zhao, Pengkun, Huo, Shuaidong, Fan, Jilin, Chen, Junlin, Kiessling, Fabian, Boersma, Arnold J., Göstl, Robert, Herrmann, Andreas
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252103/
https://ncbi.nlm.nih.gov/pubmed/33939872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202105404
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