Pharmacokinetic modeling and simulation support for age‐ and weight‐adjusted dosing of dabigatran etexilate in children with venous thromboembolism

BACKGROUND: Dabigatran etexilate (DE), a direct oral thrombin inhibitor, has been evaluated in children with venous thromboembolism (VTE) using oral solution, pellets, or capsules. OBJECTIVES: This study evaluated DE pharmacokinetics (PK) in children with VTE and the appropriateness of a DE pediatri...

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Bibliographic Details
Published in:J Thromb Haemost
Main Authors: Röshammar, Daniel, Huang, Fenglei, Albisetti, Manuela, Bomgaars, Lisa, Chalmers, Elizabeth, Luciani, Matteo, Halton, Jacqueline, Mitchell, Lesley G., Bergstrand, Martin, Ibrahim, Moustafa M. A., Joseph, David, Tartakovsky, Igor, Gropper, Savion, Brueckmann, Martina, Brandão, Leonardo R.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
Subjects:
THROMBOSIS
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251571/
https://ncbi.nlm.nih.gov/pubmed/33636042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15277
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