A SARS‐CoV‐2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD‐Independent Mechanism

The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS‐CoV‐2 (CoV2‐S) binds to the human angiotensin‐converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade. We used an automated selection process and identified an aptamer t...

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Publicat a:Angew Chem Weinheim Bergstr Ger
Autors principals: Schmitz, Anton, Weber, Anna, Bayin, Mehtap, Breuers, Stefan, Fieberg, Volkmar, Famulok, Michael, Mayer, Günter
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
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Forschungsartikel
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8250900/
https://ncbi.nlm.nih.gov/pubmed/34230708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ange.202100316
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