Neutralizing Aptamers Block S/RBD‐ACE2 Interactions and Prevent Host Cell Infection

The receptor‐binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 spike (S) protein plays a central role in mediating the first step of virus infection to cause disease: virus binding to angiotensin‐converting enzyme 2 (ACE2) receptors on human host cells. Therefore, S/RBD is...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Liu, Xiaohui, Wang, Yi‐ling, Wu, Jacky, Qi, Jianjun, Zeng, Zihua, Wan, Quanyuan, Chen, Zhenghu, Manandhar, Pragya, Cavener, Victoria S., Boyle, Nina R., Fu, Xinping, Salazar, Eric, Kuchipudi, Suresh V., Kapur, Vivek, Zhang, Xiaoliu, Umetani, Michihisa, Sen, Mehmet, Willson, Richard C., Chen, Shu‐hsia, Zu, Youli
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8250721/
https://ncbi.nlm.nih.gov/pubmed/33684258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202100345
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