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The Fluorescent Dye 1,6 Diphenyl 1,3,5 Hexatriene Binds to Amyloid Fibrils Formed by Human Amylin and Provides a New Probe of Amylin Amyloid Kinetics

The fluorescent dye 1,6-diphenyl-1,3,5-hexatriene (DPH) is widely used as a probe of membrane order. We show that DPH also interacts with amyloid fibrils formed by human amylin (h-amylin, also known as islet amyloid polypeptide) in solution and this results in a 100-fold increase in DPH fluorescence...

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書目詳細資料
發表在:Biochemistry
Main Authors: Li, Ming-Hao, Manathunga, Lakshan, London, Erwin, Raleigh, Daniel P.
格式: Artigo
語言:Inglês
出版: 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249821/
https://ncbi.nlm.nih.gov/pubmed/34128641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00328
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