Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants

Antibody titers against SARS-CoV-2 slowly wane over time. Here, we examined how time affects antibody potency. To assess the impact of antibody maturation on durable neutralizing activity against original SARS-CoV-2 and emerging variants of concern (VOCs), we analyzed receptor binding domain (RBD)-s...

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Publicado no:Immunity
Main Authors: Moriyama, Saya, Adachi, Yu, Sato, Takashi, Tonouchi, Keisuke, Sun, Lin, Fukushi, Shuetsu, Yamada, Souichi, Kinoshita, Hitomi, Nojima, Kiyoko, Kanno, Takayuki, Tobiume, Minoru, Ishijima, Keita, Kuroda, Yudai, Park, Eun-Sil, Onodera, Taishi, Matsumura, Takayuki, Takano, Tomohiro, Terahara, Kazutaka, Isogawa, Masanori, Nishiyama, Ayae, Kawana-Tachikawa, Ai, Shinkai, Masaharu, Tachikawa, Natsuo, Nakamura, Shigeki, Okai, Takahiro, Okuma, Kazu, Matano, Tetsuro, Fujimoto, Tsuguto, Maeda, Ken, Ohnishi, Makoto, Wakita, Takaji, Suzuki, Tadaki, Takahashi, Yoshimasa
Formato: Artigo
Idioma:Inglês
Publicado em: The Author(s). Published by Elsevier Inc. 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249673/
https://ncbi.nlm.nih.gov/pubmed/34246326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.06.015
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