Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio

Chronic symptoms indicating excess cortical excitability follow mild traumatic brain injury, particularly repetitive mild traumatic brain injury (rmTBI). Yet mechanisms underlying post-traumatic excitation/inhibition (E/I) ratio abnormalities may differ between the early and late post-traumatic phas...

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Publicat a:Cereb Cortex
Autors principals: MacMullin, Paul, Hodgson, Nathaniel, Damar, Ugur, Lee, Henry Hing Cheong, Hameed, Mustafa Q, Dhamne, Sameer C, Hyde, Damon, Conley, Grace M, Morriss, Nicholas, Qiu, Jianhua, Mannix, Rebekah, Hensch, Takao K, Rotenberg, Alexander
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248830/
https://ncbi.nlm.nih.gov/pubmed/32676666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhaa157
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