A Phase I dose‐escalation study of two cycles carboplatin‐olaparib followed by olaparib monotherapy in patients with advanced cancer

Preclinical studies have shown synergistic effects when combining PARP1/2 inhibitors and platinum drugs in BRCA1/2 mutated cancer cell models. After a formulation change of olaparib from capsules to tablets, we initiated a dose finding study of olaparib tablets bidaily (BID) continuously with carbop...

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Foilsithe in:Int J Cancer
Main Authors: Geenen, Jill J. J., Dackus, Gwen M. H. E., Schouten, Philip C., Pluim, Dick, Marchetti, Serena, Sonke, Gabe S., Jóźwiak, Katarzyna, Huitema, Alwin D. R., Beijnen, Jos H., Schellens, Jan H. M., Linn, Sabine C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley & Sons, Inc. 2021
Ábhair:
Cancer Therapy and Prevention
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248128/
https://ncbi.nlm.nih.gov/pubmed/33539540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33498
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