Performance of Breast Cancer Polygenic Risk Scores in 760 Female CHEK2 Germline Mutation Carriers

BACKGROUND: Genome-wide association studies suggest that the combined effects of breast cancer (BC)-associated single nucleotide polymorphisms (SNPs) can improve BC risk stratification using polygenic risk scores (PRSs). The performance of PRSs in genome-wide association studies–independent clinical...

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Publicado no:J Natl Cancer Inst
Main Authors: Borde, Julika, Ernst, Corinna, Wappenschmidt, Barbara, Niederacher, Dieter, Weber-Lassalle, Konstantin, Schmidt, Gunnar, Hauke, Jan, Quante, Anne S, Weber-Lassalle, Nana, Horváth, Judit, Pohl-Rescigno, Esther, Arnold, Norbert, Rump, Andreas, Gehrig, Andrea, Hentschel, Julia, Faust, Ulrike, Dutrannoy, Véronique, Meindl, Alfons, Kuzyakova, Maria, Wang-Gohrke, Shan, Weber, Bernhard H. F, Sutter, Christian, Volk, Alexander E, Giannakopoulou, Olga, Lee, Andrew, Engel, Christoph, Schmidt, Marjanka K, Antoniou, Antonis C, Schmutzler, Rita K, Kuchenbaecker, Karoline, Hahnen, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246885/
https://ncbi.nlm.nih.gov/pubmed/33372680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djaa203
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