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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Transcellular permeation enhancers are known to increase the intestinal permeability of enalaprilat, a 349 Da peptide, but not hexarelin (887 Da). The primary aim of this paper was to investigate if paracellular permeability enhancers affected the intestinal permeation of the two peptides. This was...

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Publicado en:Acta Pharm Sin B
Autores principales: Dahlgren, David, Olander, Tobias, Sjöblom, Markus, Hedeland, Mikael, Lennernäs, Hans
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245904/
https://ncbi.nlm.nih.gov/pubmed/34221875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.12.019
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