Immunostimulatory bacterial antigen–armed oncolytic measles virotherapy significantly increases the potency of anti-PD1 checkpoint therapy

Clinical immunotherapy approaches are lacking efficacy in the treatment of glioblastoma (GBM). In this study, we sought to reverse local and systemic GBM-induced immunosuppression using the Helicobacter pylori neutrophil-activating protein (NAP), a potent TLR2 agonist, as an immunostimulatory transg...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Panagioti, Eleni, Kurokawa, Cheyne, Viker, Kimberly, Ammayappan, Arun, Anderson, S. Keith, Sotiriou, Sotiris, Chatzopoulos, Kyriakos, Ayasoufi, Katayoun, Johnson, Aaron J., Iankov, Ianko D., Galanis, Evanthia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245183/
https://ncbi.nlm.nih.gov/pubmed/34196308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141614
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