Mechanisms of anti-vesicular stomatitis virus activity of deazaneplanocin and its 3-brominated analogues

3-deazaneplanocin A (DzNep) and its 3-brominated analogues inhibit replication of several RNA viruses. This antiviral activity is attributed to inhibition of S-adenosyl homocysteine hydrolase (SAHase) and consequently inhibition of viral methyltransferases, impairing translation of viral transcripts...

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Bibliografiske detaljer
Udgivet i:Antiviral Res
Main Authors: Gibbons, Joyce Sweeney, Khadka, Sudip, Williams, Caroline G., Wang, Lin, Schneller, Stewart W., Liu, Chong, Tufariello, JoAnn M., Basler, Christopher F.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244617/
https://ncbi.nlm.nih.gov/pubmed/34019950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2021.105088
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