AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

BACKGROUND: The maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy. Bioenergetic decline is a prominent feature of chronic neurodegenerative diseases, yet the signaling mechanisms that link energy stress with neuronal dysfuncti...

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Détails bibliographiques
Publié dans:Mol Neurodegener
Auteurs principaux: Belforte, Nicolas, Agostinone, Jessica, Alarcon-Martinez, Luis, Villafranca-Baughman, Deborah, Dotigny, Florence, Cueva Vargas, Jorge L., Di Polo, Adriana
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8243567/
https://ncbi.nlm.nih.gov/pubmed/34187514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00466-z
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