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Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon
The leucine zipper-like transcriptional regulator 1 (Lztr1) is a BTB-Kelch domain protein involved in RAS/MAPK pathway regulation. Mutations in LZTR1 are associated with cancers and Noonan syndrome, the most common RASopathy. The expression and function of Lztr1 in the developing brain remains poorl...
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| izdano v: | Front Cell Dev Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8242193/ https://ncbi.nlm.nih.gov/pubmed/34222248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.673995 |
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