Efficient Embryonic Homozygous Gene Conversion via RAD51-Enhanced Interhomolog Repair

Searching for factors to improve knock-in efficiency for therapeutic applications, biotechnology, and generation of non-human primate (NHP) models of disease, we found that the strand exchange protein RAD51 can significantly increase Cas9-mediated homozygous knock-in in mouse embryos through an inte...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell
Main Authors: Wilde, Jonathan J., Aida, Tomomi, del Rosario, Ricardo C.H., Kaiser, Tobias, Qi, Peimin, Wienisch, Martin, Zhang, Qiangge, Colvin, Steven, Feng, Guoping
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240950/
https://ncbi.nlm.nih.gov/pubmed/34043941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.04.035
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados