Targeted Next-Generation Sequencing Combined With Circulating-Free DNA Deciphers Spatial Heterogeneity of Resected Multifocal Hepatocellular Carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) has a high risk of recurrence after surgical resection, particularly among patients with multifocal HCC. Genomic heterogeneity contributes to the early recurrence. Few studies focus on targeted next-generation sequencing (tNGS) to depict mutational footprin...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Lin, Jianzhen, Zhao, Songhui, Wang, Dongxu, Song, Yang, Che, Yue, Yang, Xu, Mao, Jinzhu, Xie, Fucun, Long, Junyu, Bai, Yi, Yang, Xiaobo, Zhang, Lei, Bian, Jin, Lu, Xin, Sang, Xinting, Pan, Jie, Wang, Kai, Zhao, Haitao
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240639/
https://ncbi.nlm.nih.gov/pubmed/34211467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.673248
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