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SARS‐CoV‐2 spike protein induces degradation of junctional proteins that maintain endothelial barrier integrity

BACKGROUND: SARS‐CoV‐2 enters cells through the Angiotensin‐converting enzyme 2 (ACE‐2) receptor present on the cell surface. ACE‐2 is present in many cell types including endothelial cells, where it functions to protect against oxidative damage. Reports suggest that COVID‐19 patients also showed sy...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Raghavan, Somasundaram, Kenchappa, Divya, Leo, M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239909/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fasebj.2021.35.S1.05241
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