In vitro screening identifies TRPV4 as target for endothelial barrier stabilization in COVID‐19

STUDY OBJECTIVE: Endothelial dysfunction and increased microvascular permeability are hallmarks of severe COVID‐19. At present, the extent of endothelial barrier failure and its underlying mechanisms in COVID‑19 remain unclear. We hypothesized that endothelial leak results from bioactive mediators r...

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Veröffentlicht in:FASEB J
Hauptverfasser: Michalick, Laura, Weidenfeld, Sarah, Grimmer, Benjamin, Fatykhova, Diana, Solymosi, Philip, Behrens, Felix, Dohmen, Melanie, Brack, Markus, Schulz, Sabrina, Thomasch, Elisa, Simmons, Szandor, Müller‐Redetzky, Holger, Suttorp, Norbert, Kurth, Florian, Corman, Victor, Hocke, Andreas, Witzenrath, Martin, Hippenstiel, Stefan, Kuebler, Wolfgang
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Federation of American Societies for Experimental Biology 2021
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239634/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fasebj.2021.35.S1.02273
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