Restoration of the molecular clock is tumor suppressive in neuroblastoma

MYCN activation is a hallmark of advanced neuroblastoma (NB) and a known master regulator of metabolic reprogramming, favoring NB adaptation to its microenvironment. We found that the expression of the main regulators of the molecular clock loops is profoundly disrupted in MYCN-amplified NB patients...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Moreno-Smith, Myrthala, Milazzo, Giorgio, Tao, Ling, Fekry, Baharan, Zhu, Bokai, Mohammad, Mahmoud A., Di Giacomo, Simone, Borkar, Roshan, Reddy, Karthik Reddy Kami, Capasso, Mario, Vasudevan, Sanjeev A., Sumazin, Pavel, Hicks, John, Putluri, Nagireddy, Perini, Giovanni, Eckel-Mahan, Kristin, Burris, Thomas P., Barbieri, Eveline
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238982/
https://ncbi.nlm.nih.gov/pubmed/34183658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24196-4
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