Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance

Elevated mitochondrial hydrogen peroxide (H(2)O(2)) emission and an oxidative shift in cytosolic redox environment have been linked to high-fat-diet-induced insulin resistance in skeletal muscle. To test specifically whether increased flux through mitochondrial fatty acid oxidation, in the absence o...

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Опубликовано в: :Am J Physiol Endocrinol Metab
Главные авторы: Smith, Cody D., Lin, Chien-Te, McMillin, Shawna L., Weyrauch, Luke A., Schmidt, Cameron A., Smith, Cheryl A., Kurland, Irwin J., Witczak, Carol A., Neufer, P. Darrell
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2021
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238127/
https://ncbi.nlm.nih.gov/pubmed/33813880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00010.2021
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