Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation

BACKGROUND: Pancreatic cancer is one of the most serious and lethal human cancers with a snowballing incidence around the world. The natural product celastrol has also been widely documented as a potent anti-inflammatory, anti-angiogenic, and anti-oxidant. PURPOSE: To elucidate the antitumor effect...

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Bibliografiske detaljer
Udgivet i:Onco Targets Ther
Main Authors: Youns, Mahmoud, Askoura, Momen, Abbas, Hisham A, Attia, Gouda H, Khayyat, Ahdab N, Goda, Reham M, Almalki, Ahmad J, Khafagy, El-Sayed, Hegazy, Wael A H
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2021
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238076/
https://ncbi.nlm.nih.gov/pubmed/34194230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S313933
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