Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children

AIM: Methadone exhibits significant variability in clinical response. This study explores the genetic influence of variable methadone pharmacokinetics. METHODS: This is a prospective study of methadone in children undergoing major surgery. CYP2B6 genotyping, plasma methadone and metabolite levels we...

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Veröffentlicht in:Pharmacogenomics
Hauptverfasser: Packiasabapathy, Senthil, Aruldhas, Blessed W, Zhang, Pengyue, Overholser, Brian R, Quinney, Sara K, Sadhasivam, Senthilkumar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Future Medicine Ltd 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238023/
https://ncbi.nlm.nih.gov/pubmed/34100292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2021-0039
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