Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas

Epstein–Barr virus (EBV) is a ubiquitous herpesvirus that typically causes asymptomatic infection but can promote B lymphoid tumors in the immune suppressed. In vitro, EBV infection of primary B cells stimulates glycolysis during immortalization into lymphoblastoid cell lines (LCLs). Lactate export...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Bonglack, Emmanuela N., Messinger, Joshua E., Cable, Jana M., Ch’ng, James, Parnell, K. Mark, Reinoso-Vizcaíno, Nicolás M., Barry, Ashley P., Russell, Veronica S., Dave, Sandeep S., Christofk, Heather R., Luftig, Micah A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237662/
https://ncbi.nlm.nih.gov/pubmed/34161263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022495118
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