The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs

The specification of the hepatic identity during human liver development is strictly controlled by extrinsic signals, yet it is still not clear how cells respond to these exogenous signals by activating secretory cascades, which are extremely relevant, especially in 3D self-organizing systems. Here,...

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Udgivet i:Cell Rep
Main Authors: Michielin, Federica, Giobbe, Giovanni G., Luni, Camilla, Hu, Qianjiang, Maroni, Ida, Orford, Michael R., Manfredi, Anna, Di Filippo, Lucio, David, Anna L., Cacchiarelli, Davide, De Coppi, Paolo, Eaton, Simon, Elvassore, Nicola
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237389/
https://ncbi.nlm.nih.gov/pubmed/33264615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108453
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