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Uncarboxylated osteocalcin promotes osteogenesis and inhibits adipogenesis of mouse bone marrow-derived mesenchymal stem cells via the PKA-AMPK-SIRT1 axis

Osteoporosis is a bone disease characterized by reduced bone density, thin cortical bone and large gaps in the bone's honeycomb structure, which increases the risk of bone fragility. Uncarboxylated osteocalcin (unOC), a vitamin K-dependent bone protein, is known to regulate carbohydrate and ene...

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Detalhes bibliográficos
Publicado no:Exp Ther Med
Main Authors: Gao, Le, Gong, Fang-Zi, Ma, Lu-Yao, Yang, Jian-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237271/
https://ncbi.nlm.nih.gov/pubmed/34194558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2021.10312
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