Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

PURPOSE: Dysregulation of the alternative complement pathway is a major pathogenic mechanism in age-related macular degeneration. We investigated whether locally synthesized complement components contribute to AMD by profiling complement expression in postmortem eyes with and without AMD. METHODS: A...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Demirs, John T., Yang, Junzheng, Crowley, Maura A., Twarog, Michael, Delgado, Omar, Qiu, Yubin, Poor, Stephen, Rice, Dennis S., Dryja, Thaddeus P., Anderson, Karen, Liao, Sha-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2021
Assuntos:
Physiology and Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237111/
https://ncbi.nlm.nih.gov/pubmed/34160562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.7.26
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