Modeling Cone/Cone–Rod Dystrophy Pathology by AAV-Mediated Overexpression of Mutant CRX Protein in the Mouse Retina

PURPOSE: This study aims to evaluate the pathogenesis of cone/cone–rod dystrophy (CoD/CoRD) caused by a cone–rod homeobox (CRX) mutation, which was identified in a Chinese family, through adeno-associated virus (AAV)-mediated overexpression of mutant CRX protein in the mouse retina. METHODS: Compreh...

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Udgivet i:Transl Vis Sci Technol
Main Authors: Wang, Yuwei, Li, Xiaomeng, Yu, Yang, Liang, Jian, Liu, Yang, Chen, Yuhong, Bai, Xinyue, Chen, Jieqiong, Wang, Fenghua, Luo, Xueting, Sun, Xiaodong
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237110/
https://ncbi.nlm.nih.gov/pubmed/34144598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.10.7.25
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