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Dense and pleiotropic regulatory information in a developmental enhancer

Changes in gene regulation underlie much of phenotypic evolution(1). However, our understanding of the potential for regulatory evolution is biased, because most evidence comes from either natural variation or limited experimental perturbations(2). Using an automated robotics pipeline, we surveyed a...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Fuqua, Timothy, Jordan, Jeff, van Breugel, Maria Elize, Halavatyi, Aliaksandr, Tischer, Christian, Polidoro, Peter, Abe, Namiko, Tsai, Albert, Mann, Richard S., Stern, David L., Crocker, Justin
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236315/
https://ncbi.nlm.nih.gov/pubmed/33057197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2816-5
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