A paired-agent fluorescent molecular imaging strategy for quantifying antibody drug target engagement in in vivo window chamber xenograft models

A paired-agent fluorescent molecular imaging strategy is presented as a method to measure drug target engagement in whole tumor imaging. The protocol involves dynamic imaging of a pair of targeted and control imaging agents prior to and following antibody therapy. Simulations demonstrated that antib...

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Pubblicato in:Proc SPIE Int Soc Opt Eng
Autori principali: Kayaalp Nalbant, Elif, Rounds, Cody, Sadeghipour, Negar, Meng, Boyu, Folaron, Margaret R., Haldar, Chandrika, Strawbridge, Rendall R., Samkoe, Kimberley S., Davis, Scott C., Tichauer, Kenneth M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236091/
https://ncbi.nlm.nih.gov/pubmed/34183872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1117/12.2545182
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