Transient knockdown of Anopheles stephensi LRIM1 using RNAi increases Plasmodium falciparum sporozoite salivary gland infections

BACKGROUND: Plasmodium falciparum (Pf) sporozoites (PfSPZ) can be administered as a highly protective vaccine conferring the highest protection seen to date. Sanaria® PfSPZ vaccines are produced using aseptically reared Anopheles stephensi mosquitoes. The bionomics of sporogonic development of P. fa...

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Bibliographic Details
Published in:Malar J
Main Authors: Billingsley, Peter F., George, Kasim I., Eappen, Abraham G., Harrell, Robert A., Alford, Robert, Li, Tao, Chakravarty, Sumana, Sim, B. Kim Lee, Hoffman, Stephen L., O’Brochta, David A.
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8235909/
https://ncbi.nlm.nih.gov/pubmed/34174879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-021-03818-8
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